NanoVIVO™  Magnetic CLIO Nanoparticle Line

Dextran coated magnetic cross-linked iron oxide nanoparticles (CLIO) have superparamagnetic Fe3O4 iron oxide core (8-10 nm in diameter) imbedded within the matrix of dextran sugar strands of 40 or 70 kDa in size. Dextran strands are cross-linked to prevent their disassociation, ensuring long-term stability during storage and in biological fluids, such as blood. Due to the dextran sugar coat CLIO particles are highly biocompatible and have a long blood half life, making them optimal for both in vitro and in vivo applications. 

Magnetic CLIO Nanoparticle Products
Fluorescently Labeled Magnetic CLIO Nanoparticle Products

Fluorescent molecules are directly conjugated to the nanoparticle surface. Our standard dyes include AFDye 488, Cy3, Cy5, and IR 750. AFDye 488 and IR 750 are mimics of AlexaFluor® 488 and IRDye® 750 with very similar structure and spectral properties. Functionalizations with other dyes are available upon request.